New Ultrafast Camera Takes 70 Trillion Pictures Per Second
05-04-20
A new camera developed by Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, is capable of taking as many as 70 trillion frames per second. The camera technology, which Wang calls compressed ultrafast spectral photography (CUSP), combines a laser that emits extremely short pulses of laser light that last only one quadrillionth of a second (one femtosecond) with optics and a specialized type of camera. The technology could open up new avenues of research in fields that include fundamental physics, next-generation semiconductor miniaturization, and the life sciences. "We envision applications in a rich variety of extremely fast phenomena, such as ultrashort light propagation, wave propagation, nuclear fusion, photon transport in clouds and biological tissues, and fluorescent decay of biomolecules, among other things," Wang says. [Caltech story]
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Professor Wang Advances Photoacoustic Imaging Technology
02-25-20
Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has developed variants of photoacoustic imaging that can show organs moving in real time, develop three-dimensional (3-D) images of internal body parts, and even differentiate cancerous cells from healthy cells. Photoacoustic imaging, a technique for examining living materials through the use of laser light and ultrasonic sound waves, has many potential applications in medicine because of its ability to show everything from organs to blood vessels to tumors. Wang has now further advanced photoacoustic imaging technology with what he calls Photoacoustic Topography Through an Ergodic Relay (PATER), which aims to simplify the equipment required for imaging of this type. [Caltech story]
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Professor Wang Develops World's Fastest Camera
01-21-20
Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has developed the world's fastest camera, a device capable of taking 10 trillion pictures per second. It's so fast that it can even capture light traveling in slow motion. "What we've done is to adapt standard phase-contrast microscopy so that it provides very fast imaging, which allows us to image ultrafast phenomena in transparent materials," says Wang. [Caltech story]
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Lasers Aim to Replace Scalpels in Cutting-Edge Biopsy Technique
05-16-19
Professor Lihong Wang and Postdoctoral Scholar Dr. Junhui Shi have developed a new imaging technique that uses pulses from two kinds of lasers to take pictures of microscopic biological structures. This new approach, called ultraviolet-localized mid-infrared photoacoustic microscopy, or ULM-PAM, develops images of the microscopic structures found in a piece of tissue by bombarding the sample with both infrared and ultraviolet laser light. "Because ultraviolet light and infrared have different properties, we had to find special mirrors and glass that could focus both," Dr. Shi says. "And because no camera exists that can see both, we had to develop ways to see if they were correctly focused." [Caltech story]
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Laser Technology Helps Researchers Scrutinize Cancer Cells
04-01-19
Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, and colleagues are using photoacoustic microscopy (PAM) to improve on an existing technology for measuring the oxygen-consumption rate (OCR). This new method allows the researchers to determine how oxygenated a sample of blood is by "listening" to the sound it makes when illuminated by the laser. Professor Wang calls this single-cell metabolic photoacoustic microscopy, or SCM-PAM. [Caltech story]
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The Possibilities are Mote and Remote
08-17-18
Professor Azita Emami’s work in high-speed data communications has led to a breakthrough that could spare millions of people the need to prick themselves with needles. As she engineers a more connected world, she also is working to make it a healthier one. Professor Emami doesn’t draw a line between the different endeavors. “Electronic systems for cell phones and computers are very, very advanced,” she explains. “So why not take the knowledge we have gained developing those technologies and find ways to apply it toward solutions in medicine?” [Breakthrough story]
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Wireless Pressure-Sensing Eye Implant Could Help Prevent Blindness
06-28-18
Azita Emami, Andrew and Peggy Cherng Professor of Electrical Engineering and Medical Engineering and Executive Officer for Electrical Engineering, Yu-Chong Tai, Anna L. Rosen Professor of Electrical Engineering and Medical Engineering; Andrew and Peggy Cherng Medical Engineering Leadership Chair; Executive Officer for Medical Engineering, and colleagues have developed a new pressure-sensing implant for the eye that could help prevent one of the leading causes of blindness. The implant could help glaucoma patients monitor their condition by wirelessly sending data about the eye to the patient or medical professionals. Patients at risk for glaucoma are required to make regular visits to an ophthalmologist to have their intraocular pressure (eye pressure) checked. The disadvantage is that patients are only able to measure pressure while visiting their doctor. With a wireless implant, a patient has access to their eye pressure data at any time, and continuous monitoring will allow intervention sooner if needed. [Caltech story]
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