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Seeing Through Opaque Media

05-12-20

Changhuei Yang, Thomas G. Myers Professor of Electrical Engineering, Bioengineering, and Medical Engineering, has developed a technique that combines fluorescence and ultrasound to peer through opaque media, such as biological tissue. "We hope that one day this method can be deployed to extend the operating depth of fluorescence microscopy and help image fluorescent labeled cells deep inside living animals," says Yang. [Caltech story]

Tags: EE research highlights Changhuei Yang MedE

New Ultrafast Camera Takes 70 Trillion Pictures Per Second

05-04-20

A new camera developed by Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, is capable of taking as many as 70 trillion frames per second. The camera technology, which Wang calls compressed ultrafast spectral photography (CUSP), combines a laser that emits extremely short pulses of laser light that last only one quadrillionth of a second (one femtosecond) with optics and a specialized type of camera. The technology could open up new avenues of research in fields that include fundamental physics, next-generation semiconductor miniaturization, and the life sciences. "We envision applications in a rich variety of extremely fast phenomena, such as ultrashort light propagation, wave propagation, nuclear fusion, photon transport in clouds and biological tissues, and fluorescent decay of biomolecules, among other things," Wang says. [Caltech story]

Tags: EE research highlights MedE Lihong Wang

Best Student Paper Award at IEEE CICC Conference´╗┐

03-25-20

Professor Azita Emami's group in collaboration with Professor Wei Gao’s group has won the best student paper award at the 2020 IEEE Custom Integrated Circuits Conference. The title of the paper is "A Fully-Integrated Biofuel-Cell-Based Energy Harvester with 86% Peak Efficiency and 0.25V Minimum Input Voltage Using Source-Adaptive MPPT." The IEEE CICC is a premier conference devoted to integrated circuit development. The conference program is a blend of oral presentations, exhibits, panels and forums. The conference sessions present original first published technical work and innovative circuit techniques that tackle practical problems. [Read the paper] [Past recipients]

Tags: EE honors MedE Kuan-Chang Chen Azita Emami Wei Gao Arian Hashemi You Yu Abhinav Agarwal William Kuo Minwo Wang Gudrun Hoskuldsdottir

Professor Wang Advances Photoacoustic Imaging Technology

02-25-20

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has developed variants of photoacoustic imaging that can show organs moving in real time, develop three-dimensional (3-D) images of internal body parts, and even differentiate cancerous cells from healthy cells. Photoacoustic imaging, a technique for examining living materials through the use of laser light and ultrasonic sound waves, has many potential applications in medicine because of its ability to show everything from organs to blood vessels to tumors. Wang has now further advanced photoacoustic imaging technology with what he calls Photoacoustic Topography Through an Ergodic Relay (PATER), which aims to simplify the equipment required for imaging of this type. [Caltech story]

Tags: EE research highlights MedE Lihong Wang

Professor Wang Develops World's Fastest Camera

01-21-20

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has developed the world's fastest camera, a device capable of taking 10 trillion pictures per second. It's so fast that it can even capture light traveling in slow motion. "What we've done is to adapt standard phase-contrast microscopy so that it provides very fast imaging, which allows us to image ultrafast phenomena in transparent materials," says Wang. [Caltech story]

Tags: EE research highlights MedE Lihong Wang

Microrobots Activated by Laser Pulses Show Promise For Treating Tumors

07-24-19

MedE Professors Wei Gao and Lihong Wang are working on microrobots that can deliver drugs to specific spots inside the body while being monitored and controlled from outside the body. "These micromotors can penetrate the mucus of the digestive tract and stay there for a long time. This improves medicine delivery," Professor Gao says. "But because they're made of magnesium, they're biocompatible and biodegradable." [Caltech story]

Tags: EE research highlights MedE Lihong Wang Wei Gao

Lasers Aim to Replace Scalpels in Cutting-Edge Biopsy Technique

05-16-19

Professor Lihong Wang and Postdoctoral Scholar Dr. Junhui Shi have developed a new imaging technique that uses pulses from two kinds of lasers to take pictures of microscopic biological structures. This new approach, called ultraviolet-localized mid-infrared photoacoustic microscopy, or ULM-PAM, develops images of the microscopic structures found in a piece of tissue by bombarding the sample with both infrared and ultraviolet laser light. "Because ultraviolet light and infrared have different properties, we had to find special mirrors and glass that could focus both," Dr. Shi says. "And because no camera exists that can see both, we had to develop ways to see if they were correctly focused." [Caltech story]

Tags: EE research highlights MedE Lihong Wang postdocs Junhui Shi

Laser Technology Helps Researchers Scrutinize Cancer Cells

04-01-19

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, and colleagues are using photoacoustic microscopy (PAM) to improve on an existing technology for measuring the oxygen-consumption rate (OCR). This new method allows the researchers to determine how oxygenated a sample of blood is by "listening" to the sound it makes when illuminated by the laser. Professor Wang calls this single-cell metabolic photoacoustic microscopy, or SCM-PAM. [Caltech story]

Tags: EE research highlights MedE Lihong Wang

President Rosenbaum Highlights Postdocs as "Unsung Heroes"

09-24-18

In a letter to the Caltech community during National Postdoc Appreciation Week, the Caltech President emphasizes the role this key group plays at the Institute. He stated, “Caltech's mission of world-leading research and education depends crucially on our postdoctoral scholars. Although their time at Caltech may be short, they quickly become vital parts of the Institute's intellectual fabric.” [President’s Letter] [EAS Postdoc Resource Page]

Tags: APhMS EE GALCIT MedE MCE CMS ESE Thomas Rosenbaum postdocs

The Possibilities are Mote and Remote

08-17-18

Professor Azita Emami’s work in high-speed data communications has led to a breakthrough that could spare millions of people the need to prick themselves with needles. As she engineers a more connected world, she also is working to make it a healthier one. Professor Emami doesn’t draw a line between the different endeavors. “Electronic systems for cell phones and computers are very, very advanced,” she explains. “So why not take the knowledge we have gained developing those technologies and find ways to apply it toward solutions in medicine?” [Breakthrough story]

Tags: EE research highlights MedE Azita Emami