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Microrobots Activated by Laser Pulses Show Promise For Treating Tumors

07-24-19

MedE Professors Wei Gao and Lihong Wang are working on microrobots that can deliver drugs to specific spots inside the body while being monitored and controlled from outside the body. "These micromotors can penetrate the mucus of the digestive tract and stay there for a long time. This improves medicine delivery," Professor Gao says. "But because they're made of magnesium, they're biocompatible and biodegradable." [Caltech story]

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Lasers Aim to Replace Scalpels in Cutting-Edge Biopsy Technique

05-16-19

Professor Lihong Wang and Postdoctoral Scholar Dr. Junhui Shi have developed a new imaging technique that uses pulses from two kinds of lasers to take pictures of microscopic biological structures. This new approach, called ultraviolet-localized mid-infrared photoacoustic microscopy, or ULM-PAM, develops images of the microscopic structures found in a piece of tissue by bombarding the sample with both infrared and ultraviolet laser light. "Because ultraviolet light and infrared have different properties, we had to find special mirrors and glass that could focus both," Dr. Shi says. "And because no camera exists that can see both, we had to develop ways to see if they were correctly focused." [Caltech story]

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Laser Technology Helps Researchers Scrutinize Cancer Cells

04-01-19

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, and colleagues are using photoacoustic microscopy (PAM) to improve on an existing technology for measuring the oxygen-consumption rate (OCR). This new method allows the researchers to determine how oxygenated a sample of blood is by "listening" to the sound it makes when illuminated by the laser. Professor Wang calls this single-cell metabolic photoacoustic microscopy, or SCM-PAM. [Caltech story]

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Professor Wang Receives Biophotonics Award

02-28-18

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has received the 2018 Michael S. Feld Biophotonics Award from the Optical Society (OSA) for “invention of the world’s fastest two-dimensional receive-only camera; enabling real-time imaging of the fastest phenomena on earth.” The award recognizes individuals for their innovative and influential contributions to the field of biophotonics, regardless of their career stage. [OSA release]

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Professor Wang Elected to the National Academy of Engineering

02-07-18

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has been elected to the National Academy of Engineering (NAE). Professor Wang was elected for "inventions in photoacoustic microscopy enabling functional, metabolic, and molecular imaging in vivo." Election to the National Academy of Engineering is among the highest professional distinctions accorded to an engineer. Academy membership honors those who have made outstanding contributions to "engineering research, practice, or education, including, where appropriate, significant contributions to the engineering literature," and to the "pioneering of new and developing fields of technology, making major advancements in traditional fields of engineering, or developing/implementing innovative approaches to engineering education." [Caltech story] [NAE release]

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Laser-Imaging Technology Brought into Focus

10-26-17

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, and colleagues have improved a technique for taking three-dimensional (3-D) microscopic images of tissue, allowing them to see inside living creatures with greater precision than before. "This gives us the ability to look through opaque materials and see what's inside," Professor Wang says. "It's like an extension of the human eye, like Superman's X-ray vision."  [Caltech story]

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Cutting Down on Cancer Surgeries

05-17-17

Engineers at the Optical Imaging Laboratory led by Professor Lihong Wang have developed an imaging technology that could help surgeons removing breast cancer lumps confirm that they have cut out the entire tumor—reducing the need for additional surgeries. “What if we could get rid of the waiting? With 3D photoacoustic microscopy, we could analyze the tumor right in the operating room, and know immediately whether more tissue needs to be removed,” Professor Wang explains. [Caltech story]

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Laser-Induced Sound Waves Provide Live Panoramic Views of Tissue Functions

05-10-17

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, and colleagues are now able to take a live look at the inner workings of a small animal with enough resolution to see active organs, flowing blood, circulating melanoma cells, and firing neural networks. "Photoacoustic tomography combines light and sound synergistically for high-resolution imaging of molecular contrast," says Professor Wang. [Caltech story] [Read the paper]

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Seeing Deeper: An Interview with Lihong Wang

03-10-17

Using a combination of light and sound, Professor Lihong Wang is noninvasively peering deeper inside biological tissues than previously possible. His team uses three-dimensional photoacoustic microscopy and functional photoacoustic computed tomography to generate detailed color images of tumors and other structures inside the body. [Interview with Prof. Wang]

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